Aging and glycative stress are major, interrelated drivers of skeletal fragility, yet the extent to which they act through shared versus distinct biological pathways remains poorly defined, limiting integrated therapeutic strategies. This review compares the convergent and divergent mechanisms by which aging and glycat...
Salvador Peñarrubia, E. Martín-Guerrero, A. Gortázar et al.· Cells· 0 citations
Gaucher disease (GD) is caused by recessive mutations in the GBA1 gene (Glucosylceramidase beta 1) generating lysosomal accumulation of glucosylceramides. Bone phenotypes related to GD include Erlenmeyer flask deformity, osteosclerosis, osteonecrosis, osteopenia, and bone pain. Lysosomes modulate osteoclast differentia...
J. Patiño-Salazar, J. D. Gutiérrez-Ávila, S. Heredero-Jiménez et al.· Calcified Tissue Internation...· 0 citations
Mice with senescent CD4+ T cells displayed reduced bone mineral density and impaired structural integrity, likely due to enhanced osteoclastic activity at the expense of osteoblast function, combined with diminished responsiveness to hormonal regulation resulting from decreased receptor expression.
Daniel Cabello-Rivera, Rosa Plaza-Clavero, Luna Ballesteros-Arias et al.· European Journal of Endocrin...· 0 citations
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