Oct 2026
Genotype and arrhythmic risk in dilated cardiomyopathy.
K. Padalia, A. Fornaro, B. Claggett et al.
· European Heart Journal · 0 citations
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Sep 2026
Atrial Fibrillation in Genotyped Dilated Cardiomyopathy: Epidemiology, Risk Factors, and Outcomes: Insights From the SHaRe Registry.
BACKGROUND Atrial fibrillation (AF) is the most common arrhythmia in dilated cardiomyopathy (DCM) and is associated with adverse outcomes. However, the genetic determinants of AF risk and its prognostic significance across genotyped DCM subtypes remain unknown. METHODS In this observational cohort study, we analyzed...
I. Balakrishnan, A. Heymans, B. Claggett et al.
· Circulation: Heart Failure · 0 citations
Mapping and rewiring the MYBPC3 promoter for rescue of haploinsufficiency driven hypertrophic cardiomyopathy
This work presents a variant-agnostic approach to rescue haploinsufficiency by mapping and rationally redesigning the MYBPC3 promoter and identifies synergistic sequence edits that drive robust increases in MYBPC3 expression.
Aaron Renberg, S. Coppersmith, Owen Merritt et al.
· bioRxiv · 0 citations
Genomic Engineering of Gene Dosage: A Generalizable Framework for Modeling Haploinsufficiency-Mediated Human Disorders through Splicing Modulation
A generalizable framework to modulate gene dosage by alternative splicing via genome editing is presented, allowing high-fidelity animal models for human diseases caused by haploinsufficiency and leaving endogenous gene expression regulatory logic intact.
Eric D. Smith, Joshua K. Meisner, Abbey Bullard et al.
· bioRxiv · 0 citations