A. Jégou

Action of cofilin on ADP-Pi-containing actin filaments

In cells, the disassembly of actin filaments is tightly controlled by molecular mechanisms where cofilin plays a central role. Cofilin binds to actin filaments cooperatively, forming clusters that lead to the severing of the filaments. Since cofilin binds preferentially filaments that have hydrolysed ATP and released i...

Myosin-X sorts actin filaments into parallel bundles and tunes barbed-end dynamics

Whether a molecular motor can spontaneously organize actin filaments into bundles has remained an open question despite decades of investigation. Here, we show that the dimeric myosin-X, essential for filopodia initiation and extension in cells, is capable of sorting actin filaments into parallel bundles, gathering bar...

Intrafilament nucleotide exchange in a prokaryotic actin homolog