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Author

A. Kostareva

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#protein folding Open access Oct 2026

Associations of the single nucleotide polymorphism rs2228145 of the IL6R gene with features of the clinical course of hypertrophic cardiomyopathy

Introduction. The study of modifiable cardiometabolic risk factors (CMRFs) influencing the clinical phenotype of hypertrophic cardiomyopathy (HCM) is currently relevant. It is known that modifier genes can affect the course and progression of symptoms in HCM. At the same time, the analysis of associations between si...

T. Bezhanishvili, E. Semernin, V. G. Ilyina et al. · 0 citations
Open access Sep 2026

Clinical history shapes the predictive value of polygenic risk

For most diseases, whether PRS improves prediction beyond clinical data remains unknown, as existing evidence is concentrated in a handful of conditions with established risk models. Using 900,000 participants from UK Biobank and FinnGen, we developed and validated models for predicting 150 diseases and all-cause morta...

D. Usoltsev, I. Molotkov, N. Kolosov et al. · 0 citations
Review Open access Aug 2026

Pregnancy as a risk factor for decompensated heart failure in carriers of truncating titin gene variants: two case reports

Aim . To characterize the pregnancy and postpartum period in carriers of truncating TTN gene variants with a phenotype of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) with increased left ventricular (LV) trabeculation, and to evaluate the potential role of pregnancy as a trigger for deco...

I. S. Danilevich, E. Karelkina, A. Ryzhkov et al. · 0 citations
Open access Sep 2026

Genomic spectrum of congenital heart disease combined with kidney and urinary tract anomalies uncovered by exome sequencing and array-CGH

ROBO1 can be regarded as a candidate gene associated with combined heart and kidney structural defects and should be included in appropriate diagnostic gene-sequencing panels and support the usefulness of WES and array-based comparative genomic hybridization (array-CGH) analysis for new candidate gene identification, m...

A. Zlotina, Sergei Zhuk, I. Kozyrev et al. · 0 citations

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