A. Kriznik

TP-Ring and ZN-Ring Systems Allow Efficient Protein Clamping, Solubilization and Stabilization

Improving recombinant protein stability remains a central challenge in biotechnology, as many proteins exhibit limited robustness during production and use. Here, we introduce two intramolecular “clamping” systems, termed ZN-ring and TP-ring, that exploit ultrastable noncovalent protein–protein interactions to constr...