Author

A. Lowy

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Sep 2026

Abstract B014: Leveraging dynamic epigenetic landscapes to decode tumor-associated macrophages in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with 90% of patients developing resistance to standard chemotherapy, such as gemcitabine/paclitaxel protein-bound (GnP). PDAC tumors are characteristically immunosuppressive and fibrotic due to programs activated in tumor-associated macrophages (TA...

Debbie K. Ledezma, K. Gulay, Hervé Tiriac et al. · Cancer Research · 0 citations

Sep 2026

Abstract B054: Combined RAS Inhibition and Immune Checkpoint Blockade Overcome NF-κB-Mediated Immune Evasion in Chemoresistant Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Surgery is the only potentially curative treatment, yet approximately 85% of patients present with unresectable disease. For these patients, chemotherapy remains the standard treatment, though nearly all develop resistance and diseas...

K. Gulay, A. Martsinkovskiy, A. Lowy et al. · Cancer Research · 0 citations

Sep 2026

Abstract A054: MICAL2 promotes oncogenic Kras -induced pancreatic cancer initiation by regulating RAC1-mediated acinar to ductal metaplasia

Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of pancreatic cancer with the poorest 5-year survival rate among all solid cancers. Therefore, identifying effective therapeutic strategies is crucial for treating this disease. Using a genome-wide screening approach to find novel and targetable factors in huma...

Nirakar Rajbhandari, Deepa Sheik Pran Babu, E. Mose et al. · Cancer Research · 0 citations

Review Sep 2026

Abstract PR002: Surveillance-detected pancreatic cancers: Updated report from the PRECEDE Consortium

The Pancreatic Cancer Early Detection (PRECEDE) Consortium is a multinational prospective longitudinal cohort study of participants with elevated heritable risk for pancreatic adenocarcinoma (PC). PRECEDE aims to support surveillance for high-risk individuals (HRIs) to inform clinical practice and public health p...

R. Wadlow, Samuel D. Newton, Jessica N. Everett et al. · Cancer Research · 0 citations

#protein folding Sep 2026

Abstract A065: Mutant GNAS drives cAMP/PDE/AMP–pAMPK signaling and therapeutic synergy with combined CDK4/6 and RAS inhibition in mucinous pancreatic neoplasia

Intraductal Papillary Mucinous Neoplasm (IPMN) are pre-malignant lesions of the pancreas with frequent co-mutations in KRAS and GNAS oncogenes. We recently reported pancreatic neoplasia from both primary and metastatic disease with KRAS/GNAS mutations are sensitive to single agent treatment with the FDA approved cell...

Deepa Sheik Pran Babu, Shira Yomtoubian, Ethan Tabibzadeh et al. · Cancer Research · 0 citations