The C-Terminal Phenylalanine of the Thanatin-like Peptide Rip-2 Contributes to Its Enhanced LptA-Associated Antimicrobial Activity Compared with Thanatin
Findings support an important role for the Rip-2 C-terminal Phe18 aromatic residue in the enhanced activity of this peptide relative to thanatin and provide a framework for the rational design of more potent thanatin-derived antibiotics.