From iPSC Disease Modeling to Epigenome Editing: Toward Therapeutic Reversal of Genomic Imprinting Disorders.
How iPSC-based disease modeling is evolving from a platform for mechanism discovery toward a test bed for therapeutic epigenome engineering is discussed and the major challenges that must be addressed are outlined before epigenome editing can be translated to patients with imprinting disorders.
A. Nemoto, Hideyuki Okano
· Neurosciences research · 0 citations