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Author

A. Odugbemi

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Open access Aug 2026

In silico identification of selective cyclodecapeptide inhibitors targeting Plasmodium falciparum Grp78 chaperone

This study sought to identify peptides that mimic the substrates of PfGrp78, which can be potential inhibitors of PfGrp78, and explored the mechanism of action of cyclodecapeptides, gramicidin S (GS) and tyrocidines (Trcs), which were previously shown to exhibit potent antimalarial activity.

Wendy Mthembu, A. Odugbemi, F. L. Muzenda et al. · 0 citations
#protein folding Review Open access Aug 2026

Exploiting ER proteostasis in malaria: protein disulphide isomerases as selective antimalarial targets.

PfPDI inhibitors are most likely to succeed as components of resistance-robust combination therapies, and progress will depend on structure-guided targeting of divergent non-catalytic surfaces, optimization of intracellular and ER exposure, and rigorous in-parasite target-engagement studies.

A. Odugbemi, Wendy Mthembu, Tawanda Zininga · 0 citations

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