Nanodiscs and bicelles are widely used as membrane mimetics for structural studies of membrane-associated systems. Studies have reported that their magnetic alignment behavior and phase stability are highly sensitive to composition and temperature. In this study, we systematically investigate the effects of cholesterol...
Md Rokonujjaman, Sungsool Wi, A. Ramamoorthy· bioRxiv· 0 citations
It is demonstrated that the structural polymorphism of HEWL fibrils governs both the architecture and biological activity of cross-seeded insulin fibrils, highlighting amyloid polymorphism as an important determinant of heterologous amyloid propagation and a potential design principle for engineering functional amyloid...
S. Metkar, Vijay Eerati, A. Ramamoorthy· bioRxiv· 0 citations
Using coarse-grained molecular dynamics (CG-MD), this work captures the de novo formation of 4F nanodiscs with DMPC and reveals a multistep assembly pathway involving nucleation, fusion, and ellipse-to-disc maturation, validating the ability of CG-MD to resolve nanodisc assembly mechanisms.
Bikash R. Sahoo, B. Krishnarjuna, Thirupathi Ravula et al.· Journal of Colloid and Inter...· 0 citations
This review discusses the recent developments of lipid nanodiscs for drug delivery, focusing on design strategies, functionalization methods, and key challenges for potential clinical translation.
Thirupathi Ravula, C. N. Obi, A. Ramamoorthy· Colloids and Surfaces B: Bio...· 0 citations
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