Author

A. S. Hauser

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Open access Aug 2026

Systematic profiling reveals broad G protein coupling and context-dependent modulation of cyclic AMP by the orphan receptor GPR139.

BACKGROUND AND PURPOSE G protein-coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear. This study aimed to systematically define the G pro...

Boris Trapkov, Hans Bräuner, A. S. Hauser · British Journal of Pharmacol... · 0 citations

Review Open access Jul 2026

PrimeKG-Plus: a refreshed and rare-disease-enriched precision medicine knowledge graph

PrimeKG-Plus restores the temporal relevance of PrimeKG, providing an updated resource for drug repurposing, rare-disease research, and downstream machine-learning applications.

Trinh-Trung-Duong Nguyen, T. Nguyen-Phuong, Quy-Hoai Nguyen et al. · bioRxiv · 0 citations

Jul 2026

Peptide ligand discovery of G protein-coupled receptors

This Primer outlines experimental and computational workflows tailored to peptide–GPCR interactions, including in silico peptide mining, deorphanization strategies, library-based screening platforms, modern pathway-resolved biosensor assays, and approaches for peptide stabilization and optimization strategies to addres...

J. Hermes, Marin Matic, H. Yeung et al. · Nature Reviews Methods Prime... · 0 citations