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Author

A. Teich

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Open access Sep 2026

Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease

Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD) and is particularly pronounced in individuals carrying the APOE ε4 allele, but the mechanisms linking APOE ε4 to BBB failure remain unclear. Here we show that astrocyte-derived fibronectin (FN1) is a key mediator of apolipoprotein E4...

P. Bhattarai, E. Yılmaz, Elif Öykü Cakir et al. · 1 citation
#protein folding Open access Aug 2026

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

A scalable, open-source, deep-learning approach to quantify NFT burden in digital whole slide images (WSIs) of post-mortem human brain tissue and openly releases this multi-institution deep-learning pipeline to provide detailed NFT spatial distribution and morphology analysis capability at a scale otherwise infeasible...

S. Ghandian, Liane Albarghouthi, Kiana Nava et al. · 0 citations

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