Multiplexed single-molecule analysis of barcoded protein variants
Single-molecule techniques provide exceptional resolution of biomolecular dynamics but are limited by low throughput. Here, we present a DNA barcoding strategy that enables parallel kinetic profiling of multiple protein variants in a single experiment. Each protein is covalently linked to a unique DNA barcode, decode...
Stefan H. Mueller, David M. Grimson, H. Paz et al.
· Nature Communications · 0 citations