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Author

A. Williams

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Open access Aug 2026

Oligodendrocyte dysfunction in human age-related cognitive decline

Cognitive decline in aging impacts quality of life, for which therapeutic interventions are lacking. Why some individuals experience more severe cognitive decline with aging is unclear. Here we uncover a role for the brain’s myelin-forming cells—oligodendrocytes—in explaining this variance. By investigating neuropathol...

Georgina A. Craig, Emeric Merour, L. Seeker et al. · 0 citations
Open access Aug 2026

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

Inhibition of Bruton’s tyrosine kinase (BTK) limited microglial transcriptional changes and prevented myelin loss following microglial envelopment and support BTK inhibition as a therapeutic strategy to prevent demyelination by modulating microglia behavior.

Lindsay A. Osso, Helena J. Barr, Michael E. Stockton et al. · 0 citations

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