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Open access

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

Lindsay A. Osso Helena J. Barr Michael E. Stockton Maureen Wentling Stephanie Karas Rongchen Huang Graham C. Peet Katherine S. Given Arlo Simmerman Crystal R. McClain Mohammad Mansoor Dustin P. Fykstra Kellie Horan Clara Mutschler Connon I. Thomas A. Darehshouri Lan Lee Ross Gruber D. Ofengeim A. Williams Wendy B. Macklin G. Owens Jeffrey L. Bennett Ethan G. Hughes
Aug 2026 · bioRxiv · 0 citations · 87 references
Biology

TL;DR

Inhibition of Bruton’s tyrosine kinase (BTK) limited microglial transcriptional changes and prevented myelin loss following microglial envelopment and support BTK inhibition as a therapeutic strategy to prevent demyelination by modulating microglia behavior.

DOI Semantic Scholar
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