Aaron P. Ledray

A retrospective on 30 years of using peroxidases to study fundamental components of heme enzyme structure–function relationships

This review traces roughly 30 years of peroxidase engineering, built on half a century of prior enzymology and structural biology, as a case study in translational biomimicry. Beginning with the earlier work that defined Compound I and Compound II, we follow how structural biology established the peroxidase fold, how m...