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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Adele Mucci

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Sep 2026

Rational Engineering of Notch1 Signaling to Boost the Proliferation of CD19-BBζ CAR-T.

A critical role of Notch1 in CAR-T effector function is demonstrated and a novel strategy to augment endogenous Notch1 activity by leveraging native gene regulation is provided to augment endogenous Notch1 activity by leveraging native gene regulation.

M. Phillips, F. Birocchi, Felix Korell et al. · 0 citations
Open access Jul 2026

Non-genotoxic transplantation and in vivo selection through epitope editing

Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditions such as sickle c...

G. Casirati, Andrea Cosentino, Marta Freschi et al. · 0 citations

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