Probing the pH- and Voltage-Driven Intramolecular Folding Dynamics of the c -MycC52 Promoter i -Motif at the Single-Molecule Level
The human c-Myc proto-oncogene is a transcription factor that regulates protein expression and is controlled by GC-rich regulatory sequences capable of adopting non-canonical DNA secondary structures. Here, we use the α-hemolysin (α-HL) protein nanopore to probe pH- and voltage-dependent effects on the stability of t...
Adina Cimpanu, Jonggwan Park, Yoonkyung Park et al.
· Analytical Chemistry · 0 citations