Adrian Serohijos

A strategy for genome-wide seamless tagging of human protein-coding genes

A universal and scalable method based on CRISPR/Cas9-non-homologous end joining (NHEJ) for Pooled Recombinant Integration of Seamless Markers (PRISM) into protein coding genes, paving the way for genome-scale construction of human cell lines tagged with different types of reporter genes for protein functional character...

Protein–protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures

Human polygenic phenotypes arise from the combined effects of many genes that interact within molecular networks. Yet, we know little about how the structure of these networks constrains or facilitates the evolution of complex traits. Here, we systematically examine the relationship between protein–protein interaction...

Genetic landscape of an in vivo protein interactome.