Adaptive Evolution in Aminoacyl-tRNA Synthetases Drives Antibiotic Tolerance and Resistance in Clinical Klebsiella pneumoniae Isolates.
Core genome variation is highlighted as a potential contributor to antimicrobial resistance in K. pneumoniae and conserved mutations such as metG Asn366Asp may represent candidate genomic biomarkers warranting further investigation, which are regarded as hypotheses for future experimental testing.