Sep 2026
Thieno[2,3-d]pyrimidine scaffold optimization for synergistic c-Met/STAT3 blockade: Synthesis, structure-activity relationships, in vitro potency, and apoptotic pathways in colorectal cancer.
Compounds 17d and 17e were found to be the most potent and exhibited significant anticancer activity across a wide range of cancer cell lines within the NCI-60 panel and are promising leads for further development of dual c-Met/STAT3 inhibitors for treating colorectal cancer.
S. I. El-Desouky, Hesham Haffez, Mohamed S. Nafie et al.
· Bioorganic chemistry (Print) · 0 citations