Author

Ai Tian

3 papers indexed here

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Open access Sep 2026

Collapse of embryonic identities and emergence of functional diversity during motor neuron maturation.

Post-mitotic neurons undergo a protracted maturation period as they extend axons to their targets, form synapses, and refine electrophysiological properties. We use temporal single-nucleus multiome sequencing to map molecular underpinnings of maturation in mouse skeletal motor neurons (SMNs). Our data show that SMNs un...

Yi-Jia Chen, H. Chi, Ai Tian et al. · Cell Reports · 0 citations

#gene editing Open access Sep 2026

HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells

Using CRISPR-Cas9 gene editing in human pluripotent stem cells, HOPX is identified as an important regulator of oRG-like cell maintenance and the neurogenic-gliogenic balance, providing insight into the molecular programs governing human neural progenitor expansion.

Xiao-Xue Dong, Wendy W. Y. Choi, Mai Ahmed et al. · Stem Cell Reports · 0 citations

Open access Aug 2026

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

Deep long-read RNA sequencing and proteomics in induced pluripotent stem cell-derived cortical neurons is integrated to generate a high-resolution proteogenomic atlas of human neuron development, uncovering thousands of novel isoforms and revealing dynamic splicing changes in autism risk genes.

N. Xu, Katherine M. Rynard, E. Radley et al. · Nature Communications · 1 citation