Author

Ai Zhang

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Open access Sep 2026

Genomic and transcriptomic quality control for an autologous iPSC-derived cell therapy for Parkinson's disease.

Preclinical manufacturing strategy and results demonstrating efficacy in a PD rodent model and safety in a 9-month GLP toxicology study are reported.

A. Bratt-Leal, T. Gorba, Roy M. Williams et al. · Cell Stem Cell · 0 citations

Sep 2026

Integrated morphological, multi-omics, and functional profiling reveals microglial plasticity driven by AD risk genes

It is shown that depletion of these AD risk genes disrupts baseline morpho-transcriptomic coupling and fundamentally alters microglial phagocytic capacity, revealing how AD GWAS genes may drive microglia into dysfunctional states characterized by altered morphology, distinct multi-omic signatures, and impaired function...

Ying-Jie Zhang, Ai Zhang, Sang Seo et al. · bioRxiv · 0 citations