Integrated morphological, multi-omics, and functional profiling reveals microglial plasticity driven by AD risk genes

Ying-Jie Zhang Ai Zhang Sang Seo Craig Fredrickson Min Jung Xiwei Shan Lilian Phu Amber L. Cramer Carlos Sanchez-Priego V. V. Kulkarni Christopher M. Rose Casper C. Hoogenraad Claire G. Jeong

Sep 2026 · bioRxiv · 0 citations

Biology

TL;DR

It is shown that depletion of these AD risk genes disrupts baseline morpho-transcriptomic coupling and fundamentally alters microglial phagocytic capacity, revealing how AD GWAS genes may drive microglia into dysfunctional states characterized by altered morphology, distinct multi-omic signatures, and impaired functions.

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