Author

Alan D Friedman

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#gene editing Open access Oct 2026

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Adoptive transfer of proinflammatory myeloid cells enhances antitumor T‐cell responses and limits tumor growth in murine models. Previous work identified transcription factors NF‐κB p50 and STAT6 as key regulators whose inactivation enhances the inflammatory potential of murine myeloid cells. Herein, we translate murin...

Theresa Barberi, Alan D. Friedman · Molecular Oncology · 0 citations

Open access Aug 2026

A Transgenic mouse tolerant to syngeneic cancer cells expressing truncated human epidermal growth factor receptor

C57BL/6 mice in which a truncated variant of human EGFR (hEGFRt), lacking the ligand binding domain and cytoplasmic domain, is expressed from the CAG regulatory elements comprised of the CMV enhancer, β-actin promoter, and β-globin poly-adenylation signals are developed.

Theresa Barberi, Rahila Khuroo, Alan D. Friedman · PLoS ONE · 0 citations