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Author

Alejandro Valbuena

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Open access Sep 2026

Inositol Hexakisphosphate Promotes Open Pore State in HIV Capsid Protein Lattice by Reconfiguring Subunit Contacts

IP6 is established as a proviral regulator that couples nanoscale pore dynamics, intersubunit contact reconfiguration, and mechanical resilience of the HIV-1 capsid, providing a unified mechanistic framework for its role in viral replication.

Y. Knelissen, Judith Escrig, Amanda C. Macke et al. · 0 citations
Aug 2026

Distinct amyloid-β filament fold in individuals with APP Flemish mutation

Cryo-electron microscopy structures of amyloid filaments extracted from the postmortem parietal lobes of two individuals representing the only two known Flemish pedigrees worldwide provide insight into the molecular basis of Flemish-type dementia and cerebral hemorrhage.

Peerzada Shariq Shaheen Khaki, P. A. Guillen-Poza, Carlton Wong et al. · 0 citations
Open access Aug 2026

RNA-repelling Anionic Clusters in Human Rhinovirus Cooperate with Cationic Residues to Promote Virion Assembly and Restrain RNA Release.

Understanding of the capsid-RNA duplex interface in RV is expanded by addressing the structural and functional roles of conserved patches of negatively charged capsid residues interposed between each RNA duplex and its binding site at the capsid inner surface.

Valentín Riomoros-Barahona, Juan M. Martínez-Romero, Luis Valiente et al. · 0 citations
Open access Jul 2026

Biologically Relevant, Cationic Residues in Human Rhinovirus Stabilize Capsid-Bound RNA Duplexes, and Restrict Capsid Flexibility.

Comparison of the two alternative wild-type virion structures and the mutant virion structures supports the existence of two conformational states of the RV virion in the absence of cell receptor: a basal state with well-structured RNA duplexes, and an activated, RNA release-prone state in which the RNA duplexes are pa...

Juan M. Martínez-Romero, Luis Valiente, J. Vilas et al. · 1 citation

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