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Distinct amyloid-β filament fold in individuals with APP Flemish mutation

Peerzada Shariq Shaheen Khaki P. A. Guillen-Poza Carlton Wong Chloe Kan Rakesh Sharma Rio Sugimura Andrew C. Robinson Alejandro Valbuena Roy Chun-Laam Ng Yang Yang R. Hervás
Aug 2026 · Nature Structural & Molecular Biology · Vol 33, pp. 1194 - 1203 · 0 citations · 80 references
Medicine

TL;DR

Cryo-electron microscopy structures of amyloid filaments extracted from the postmortem parietal lobes of two individuals representing the only two known Flemish pedigrees worldwide provide insight into the molecular basis of Flemish-type dementia and cerebral hemorrhage.

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