Neuronal FICD shapes motivated behavior through modulation of dopamine receptor dynamics
Motivated behaviors rely on dopaminergic signaling, which in turn depends on the correct folding and trafficking of receptors through the endoplasmic reticulum (ER). Within the ER, the AMPylase enzyme FICD acts as a molecular rheostat through its modification of the chaperone BiP, dynamically tuning the organelle’s res...
KJ Weaver, Benedict Abdon, B. Toth et al.
· bioRxiv · 0 citations