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Author

Alfi Sophian

Pusat Pengembangan Pengujian Obat dan Makanan Nasional

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Review Open access Sep 2026

The Precision Nutraceutical Delivery Continuum: A Critical Review of Nanoencapsulation Strategies Bridging Pharmaceutical Engineering and Personalized Nutritional Therapy

Most bioactive nutraceuticals and many oral pharmaceuticals share a common translational bottleneck: poor aqueous solubility, gastrointestinal instability, and low systemic bioavailability that blunt their clinical and nutritional benefit. Nanoencapsulation — the entrapment of a bioactive within a nanoscale lipid, poly...

Alfi Sophian · 0 citations
Review Sep 2026

Intrinsically disordered proteins and liquid-liquid phase separation: Molecular grammar, condensate physiology, and disease-relevant phase transitions.

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins constitute a substantial and functionally critical fraction of the eukaryotic proteome. Through multivalent, low-affinity interactions encoded in their low-complexity domains (LCDs), IDPs drive liquid-liquid phase separatio...

Abinawanto, Alfi Sophian · 0 citations
Review Open access Aug 2026

Placental Extracellular Vesicles in Preeclampsia: Molecular Cargo, Pathophysiological Roles, and Emerging Diagnostic and Therapeutic Frontiers

Preeclampsia (PE) affects 2%–8% of pregnancies globally and remains a leading cause of maternal and perinatal mortality. A central clinical gap is the absence of analytically and clinically validated non‐invasive biomarkers capable of predicting PE before symptom onset. Current clinical tools, including angiogenic mark...

Marhaen Hardjo, Alfi Sophian · 0 citations
Review Sep 2026

Engineered Lipid Nanoparticles beyond mRNA Vaccines: Advances in Lipid Design, Protein Corona Dynamics, and Expanding Therapeutic Horizons

This synthesis aims to guide formulation scientists, clinician‐scientists, and regulatory professionals in advancing the next generation of LNP‐based precision nanomedicines by linking molecular lipid design to manufacturing scalability, long‐term safety, and equitable access.

T. Ikrar, Wachyudi Muchsin, Alfi Sophian · 0 citations
Review Aug 2026

Estrogen Deficiency-Induced Lipid Dysregulation in Menopause: Mechanisms, Metabolic Consequences, and Therapeutic Strategies.

Menopause is a universal physiological transition marked by the permanent cessation of ovarian estrogen secretion, with far-reaching consequences for cardiometabolic health. Among these consequences, lipid dysregulation stands as one of the most clinically significant, substantially elevating the risk of cardiovascular...

Alfi Sophian · 0 citations
#protein folding Review Open access Sep 2026

Microplastics as Emerging Neurotoxins: Brain Accumulation, Neuroinflammation, and Neurodegeneration Risk

ABSTRACT Microplastics (MPs) and nanoplastics (NPs) have emerged as ubiquitous environmental contaminants with profound implications for human neurological health. Recent landmark findings confirm the bioaccumulation of MPs/NPs in human brain tissue—with concentrations reaching 4917 μg/g in 2024 autopsy samples and up...

Alfi Sophian, Asmariani, Erika Ismayani · 0 citations

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