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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Alfonso Valencia

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2 papers indexed here

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Open access Jul 2026

Structural quality-tier assessment for TCR-pMHC functional enrichment

T cell receptor (TCR) recognition of peptide-MHC complexes (pMHCs) is central to adaptive immunity. Structural insights into TCR-pMHC interactions are critical for understanding antigen specificity and T-cell function. However, progress remains limited by the scarcity of experimentally resolved structures (275 TCR-pMHC...

Alex Ascunce-París, Miguel Romero-Durana, Alfonso Valencia et al. · 0 citations
#protein folding Open access Sep 2026

Architectonic Spandrels in the Origin of Enzymatic Function

It is found that reverse folding algorithms are unable to energetically minimize evolutionary conserved frustration at specific residues, even when detrimental to overall structural stability, and it is proposed that these frustration hotspots act as architectural spandrels, inherent physical constraints of the fold th...

Miriam Poley-Gil, Miguel Fernández-Martín, Alin Banka et al. · 2 citations

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