Evaluation of Insulin-Like Growth Factor-1 and Insulin Resistance in Patients With Central Serous Chorioretinopathy.
BACKGROUND AND OBJECTIVE This study aimed to investigate serum levels of insulin-like growth factor-1 (IGF-1) and its association with parameters related to insulin resistance, in patients diagnosed with central serous chorioretinopathy (CSCR). PATIENTS AND METHODS In this cross-sectional comparative study, patients were classified as simple (n = 30) or complex (n = 25) CSCR based on multimodal imaging findings. Following a comprehensive ophthalmologic examination, fasting venous blood samples were collected for the biochemical analysis of glucose, insulin, IGF-1, C-reactive protein (CRP), and glycated hemoglobin (HbA1c). Subsequently, body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) values were calculated for each participant. RESULTS Mean serum IGF-1 levels were significantly higher in simple and complex CSCR groups compared with controls (P < .05). No significant differences were observed among the groups in glucose, HbA1c, CRP, BMI, or HOMA-IR (P > .05). CONCLUSION Elevated IGF-1 levels in CSCR patients suggest that this growth factor may contribute to disease pathogenesis through mechanisms involving choroidal vascular permeability and retinal endothelial activity.