Evaluation of Insulin-Like Growth Factor-1 and Insulin Resistance in Patients With Central Serous Chorioretinopathy.
TL;DR
Elevated IGF-1 levels in CSCR patients suggest that this growth factor may contribute to disease pathogenesis through mechanisms involving choroidal vascular permeability and retinal endothelial activity.
Abstract
Background
AND
Objective
This study aimed to investigate serum levels of insulin-like growth factor-1 (IGF-1) and its association with parameters related to insulin resistance, in patients diagnosed with central serous chorioretinopathy (CSCR). PATIENTS AND
Methods
In this cross-sectional comparative study, patients were classified as simple (n = 30) or complex (n = 25) CSCR based on multimodal imaging findings. Following a comprehensive ophthalmologic examination, fasting venous blood samples were collected for the biochemical analysis of glucose, insulin, IGF-1, C-reactive protein (CRP), and glycated hemoglobin (HbA1c). Subsequently, body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) values were calculated for each participant.
Results
Mean serum IGF-1 levels were significantly higher in simple and complex CSCR groups compared with controls (P < .05). No significant differences were observed among the groups in glucose, HbA1c, CRP, BMI, or HOMA-IR (P > .05).
Conclusion
Elevated IGF-1 levels in CSCR patients suggest that this growth factor may contribute to disease pathogenesis through mechanisms involving choroidal vascular permeability and retinal endothelial activity.