The Disordome Paradigm: How Intrinsic Disorder Encodes Emergent Biological Function
Classical structural biology equates function with a fixed three-dimensional fold, a view challenged by intrinsically disordered proteins (IDPs) and regions (IDRs), which populate broad conformational ensembles rather than a unique structure. This article introduces the “disordome” paradigm, extending Uversky’s “unfold...
Jacques Fantini, Marine Lefebvre, Anaïs Aulas et al.
· Molecules · 0 citations