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Andreas Evers

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Open access Sep 2026

Antibody framework engineering enables augmented cytokine receptor signaling capacities of bispecific single domain antibody-based IL-21 mimetics

These findings show that IL-21 receptor agonism can be substantially optimized by adapting the spatial orientation of paratopes targeting both receptor subunits via forced dimerization, without altering paratope valencies.

Britta Lipinski, Laura Unmuth, Thi Hong Hue Tran et al. · 1 citation
#protein folding Open access Aug 2026

Quantifying molecular specificity in excipient-driven antibody solubilization

It is shown that excipient-mediated solubilization of therapeutic antibodies is markedly molecularly specific, and the integration of high-throughput experimentation with molecular feature analysis offers a foundation for improving the understanding and prediction of antibody-specific formulation behavior.

Zexiang Han, Nadia A. Erkamp, Rob M. Scrutton et al. · 0 citations
Open access Aug 2026

A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.

The AIntibody challenge shows that AI can optimize antibodies in defined, biologically grounded regimes, in addition to highlighting critical gaps including affinity prediction and library-inspired antibody design and cross-task generalization.

M. Erasmus, Daniel Bedinger, Elizabeth Hopkins et al. · 0 citations

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