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Pancreatic ductal adenocarcinoma (PDAC) disease progression involves complex cell state transitions in both malignant and non-malignant populations within the tumor microenvironment. To uncover PDAC cell states and epigenetic features associated with clinical outcome, we profiled 40 tumor samples (33 primary tumors a...
This work extensively characterized a CRISPR-engineered human hematopoietic stem and progenitor cell model of ASXL1 mutations, and is the first to functionally describe the mutant ASXL1 interactome in the context of human HSCs, identifying MECOM and BRD4 as actionable dependencies with therapeutic potential for ASXL1-m...
RIDDLER stands out as a scalable, generalizable multi-modal method for accurate CNV detection, empowering studies aiming to link CNV dynamics to epigenetic alterations within the same cell, empowering studies aiming to link CNV dynamics to epigenetic alterations within the same cell.
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