Andrey V. Golovin

NomadFlow: unindexed multi-motif scaffolding with independently mobile rigid groups

Motif scaffolding builds a protein around a prescribed structural motif -- an active site, a binding epitope, a metal site -- so that the motif is presented in its required geometry. The task is usually posed with the motif pinned down: its position along the sequence is given, and several rigid fragments inherit their...