Anees Ahmed Mahaboob Ali

Gene-level evolutionary conservation and human constraint decline at comparable rates across the age of onset of Mendelian disease

Background Gene-level constraint and conservation scores are widely used to prioritise disease genes and to benchmark genomic language models. Purifying selection acts weakly on phenotypes manifesting after reproduction, so these scores are expected to carry less information about late-onset disease. An onset-dependent...

Joint optimisation of amino acid and coding sequence for de novo designed proteins

JANUS: data and reproducibility artefacts

Derived data, run outputs and figure source data supporting the article "Joint optimisation of amino acid and coding sequence for de novo designed proteins". Includes the inverse-folding marginals for all 862 backbones and the full 230,992-row double-mutant additivity table.

JANUS: data and reproducibility artefacts

Derived data, run outputs and figure source data supporting the article "Joint optimisation of amino acid and coding sequence for de novo designed proteins". Includes the inverse-folding marginals for all 862 backbones and the full 230,992-row double-mutant additivity table.