Global Metabolic Rewiring Induced by HAC1 Overexpression Facilitates Efficient Linalool Synthesis in Saccharomyces cerevisiae.
The present study employs global transcriptional engineering (GTE) to optimize metabolic flux toward linalool synthesis by screening seven key transcription factors in Saccharomyces cerevisiae. Overexpression of HAC1 in the strain SA44, the master regulator of the unfolded protein response (UPR), increased 2.9-fold in...