Open access
Oct 2026
Force Induces a Collective Inactivity in Dyneins to Auto-Regulate Bidirectional Transport of Vesicles
It is proposed that an inactivating conformational change is induced when dynein detaches against strain from its catch-bonded state, and captured the dynamics of this process through a statistical model of Entropically Constrained Reactivation, obtaining predictions in excellent agreement with experimental data.
Dwiteeya Chaudhury, Aniket Kumar, Paulomi Sanghavi et al.
· bioRxiv · 0 citations