Author

Ao Chen

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Jul 2026

Full-length single-cell spatial transcriptomics reveals spatial and cell-type-specific transcript isoforms in the primate brain

Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.

Hengxin Liu, Yanhong Hong, Y. Zhang et al. · Nature Methods · 0 citations

Jul 2026

Spatiotemporal multiomics uncover tumor ecosystem dynamics during metastatic colonization.

A residual population of quiescent Phgdhhigh DTCs that survived initial innate immune clearance and became transiently enriched in micrometastases are identified, providing insights into the development of micrometastasis-targeting regimens.

Yun-Fan Sun, Y. Zhong, Shang Liu et al. · Science · 0 citations