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Full-length single-cell spatial transcriptomics reveals spatial and cell-type-specific transcript isoforms in the primate brain

Hengxin Liu Yanhong Hong Y. Zhang Liyuan Xi Huiying Yan Yuxuan Liu Qianqian Yang Xing Sun Shouliang Guan Zan Chen Yu Feng Tao Zeng Juan Meng Sha Liao Nini Yuan Z. Liu Chao Li Zhiyong Liu Lei Han Zhi-Jian Shen Ao Chen Yi-Di Sun Yu-Liang Dong Longqi Liu Chengyu T Li Wu Wei
Jul 2026 · Nature Methods · Vol 23, pp. 1854 - 1868 · 0 citations · 69 references
Medicine

TL;DR

Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.

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