Author

Ashley M. Cunningham

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Open access Sep 2026

KMT2E recruitment by H3 serotonylation regulates neurodevelopmental chromatin dynamics

Histone H3 Gln 5 serotonylation (H3Q5ser) is a recently identified epigenetic modification in brain that modulates reader interactions with adjacent H3 Lys 4 trimethylation (H3K4me3) to promote transcriptional permissiveness1,2. However, whether H3K4me3Q5ser and its associated binding proteins regulate neurodevelopment...

Jennifer C. O'Chan, Benjamin H. Weekley, Ce-Li Yang et al. · bioRxiv · 0 citations

Review Aug 2026

Early life experiences, the neural epigenome and affective disorder risk

Recent advances in cell-type-specific epigenetic and transcriptional mechanisms underlying long-term stress susceptibility are discussed, which suggest peripheral epigenetic signatures associated with early life stress may provide accessible biomarkers of exposure and disease risk.

Ashley M. Cunningham, I. Maze · Nature Reviews Neuroscience · 1 citation