Aug 2026· Nature Reviews Neuroscience· Vol 27, pp. 659 - 675· 1 citation· 177 references
Medicine
TL;DR
Recent advances in cell-type-specific epigenetic and transcriptional mechanisms underlying long-term stress susceptibility are discussed, which suggest peripheral epigenetic signatures associated with early life stress may provide accessible biomarkers of exposure and disease risk.
This review aims to establish an integrated framework for understanding MDD epigenetics and accelerating the development of precision diagnostic and therapeutic approaches, including small-molecule inhibitors, RNA-based modulators, and brain-targeted delivery systems.
Jia-Yu Li, Xuchu Guan, Rui-Gang Zhang et al.· Journal of Translational Med...· 0 citations
This work emphasizes the necessity of considering sex when investigating developmental and neurobiological underpinnings of stress-related disorders and displays a vast range of lasting effects of developmental stress on the brain, which provides a valuable resource for future studies aiming to improve psychiatric trea...
S. Narayan, C. Beer, V. Kovářová et al.· Proceedings of the National...· 0 citations
Abstract Background A challenge for developing new major depressive disorder (MDD) treatments is understanding how non-heritable risk factors like stress alter biological processes. We previously used preclinical animal models to demonstrate chronic psychosocial stress reorganizes the peripheral and meningeal immune mi...
S. Kigar, X. Shen, S. White et al.· International Journal of Neu...· 0 citations
Abstract Background Stress is a major etiological factor in the development of mental disorders, particularly when exposure occurs during sensitive developmental windows. Prenatal stress (PNS) has been shown to induce long-lasting behavioral and neurobiological alterations that emerge during adolescence and persist int...
M. A. Riva, V. Begni, A. Marchesin et al.· International Journal of Neu...· 0 citations
It is argued that integrating immune embedding with stress- reward recalibration may clarify one pathway by which ACEs confer SUD vulnerability and may inform trauma- informed, neurobiologically grounded approaches to prevention and treatment.
Samantha E. Clark, M. Monnig, Peter M. Monti· R.I. medical journal· 0 citations
Findings demonstrate enduring, sex-specific alterations in vagal circuit development centered on mitochondrial pathways that disrupts functional and molecular development of vagal circuitry, a key pathway for brain-body communication in mice.
Sarah Panvini, Sirajan Kamara, Matthew Hong et al.· bioRxiv· 0 citations
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