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Author

Aylin del Moral-Morales

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Review Open access Aug 2026

Advances in the emerging field of epi-informatics in drug discovery: roads taken and future prospects.

INTRODUCTION Epigenetic drug discovery remains a promising drug discovery strategy that has long been driven by advances in computational approaches. The subfield of epi-informatics, established more than a decade ago, continues to evolve rapidly as emerging machine learning methodologies reshape and expand its applica...

Aylin del Moral-Morales, Erik D. Díaz-Dionisio, José L. Medina-Franco · 0 citations
#protein folding Open access Aug 2026

Ser715 Phosphorylation Induces β-Hairpin Unfolding and Destabilization of FOXM1 Autoinhibition.

FOXM1 is a cell proliferation-driving transcription factor activated by phosphorylation-induced conformational changes. In its inactive state, an intramolecular β-hairpin within the transactivation domain (TAD) binds the N-terminal repressor domain (NRD), forming a composite β-sheet that locks the protein in an autoinh...

Sara AlRawashdeh, Raghd Obidat, Aylin del Moral-Morales et al. · 0 citations

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