Molecular Consequences and Targeting of PPM1D Overexpression in Myeloproliferative Neoplasms.
Phosphatase Mg2+/Mn2+ dependent 1D protein (PPM1D) is a serine threonine phosphatase known to regulate oncogenic pathways. PPM1D mutations are enriched in therapy-related MDS and AML, but the role of PPM1D in myeloproliferative neoplasms (MPN) remains largely unexplored. By sequencing 519 MPN patients, we detected acti...
Md. Babu Mia, Christoph Schaniel, C. Clementelli et al.
· Blood · 0 citations