Granulomatous lymphocytic interstitial lung disease (GLILD) is a non-infectious complication of common variable immunodeficiency (CVID) entailing increased morbidity and mortality. The pathogenesis of GLILD remain unclear, and optimal treatment strategies are lacking. We aimed to highlight GLILD pathogenesis and id...
M. S. A. Fraz, A. Michelsen, H. Hol et al.· ERJ Open Research· 0 citations
Many patients with common variable immunodeficiency (CVID) develop inflammatory/autoimmune complications associated with T-cell and monocyte dysregulation which may involve epigenetic modifications.
To characterize genome-wide CpG methylation in CD3
+
T-cells and CD14
+
monocytes in CVID and relate epi...
Vegard Myhre, Ming-Yi Yang, Mari Kaarbø et al.· Frontiers in Immunology· 0 citations
CRISPR/Cas9 enables precision gene editing via homology-directed repair (HDR) for mutation correction and disease modelling. Here we present a customizable T cell single nucleotide variant (SNV) correction platform based on non-viral HDR, previously described in Mamia et al.
Precision T Cell Correction Platform for...
Katariina Mamia, Anniken Solveig Matheson Sollano, Vanja Lundberg et al.· Frontiers in Genome Editing· 0 citations
TBE patients have an overall good one-year prognosis, but a minority—characterized by higher acute disease burden and comorbidities—have persistent cognitive difficulties that may warrant follow-up.
H. Skudal, Å. Lorentzen, Tore Stenstad et al.· Journal of Neurology· 0 citations
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