Author

B. Macao

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Open access Oct 2026

A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies

PZL-26 targets LONP1 with nanomolar potency and on-target cellular activity, revealing OXPHOS and mitochondrial gene expression as key survival dependencies.

Z. Szilágyi, P. Michon, Carlos Pardo-Hernández et al. · Life Science Alliance · 0 citations

Open access Jul 2026

SLIRP differentially modulates RNA binding of pathogenic LRPPRC variants

Findings highlight SLIRP’s critical role in modulating LRPPRC function and suggest that enhancing SLIRP activity represents a potential therapeutic strategy for LRPPRC-related mitochondrial disorders.

Louise Lambert, U. Rovšnik, A. Moretton et al. · NAR molecular medicine · 0 citations