Open access
A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies
Z. Szilágyi
P. Michon
Carlos Pardo-Hernández
Mãdãlina Sãcultanu
Javier Miralles Fusté
A. Griffin
Paul S. Charifson
C. Phan
Yong-Hong Shi
Gunther H. Kern
Gabriel Martínez-Botella
T. Keating
B. Macao
Nils-Göran Larsson
M. Falkenberg
J. Green
Claes M. Gustafsson
Medicine
Abstract
PZL-26 targets LONP1 with nanomolar potency and on-target cellular activity, revealing OXPHOS and mitochondrial gene expression as key survival dependencies.