Author

Bertrand Séraphin

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#protein folding Open access Oct 2026

Direct monitoring of unfolded nascent polypeptides by the CCR4-NOT complex contributes to protein quality control through selective mRNA deadenylation and decay

Accumulation of aberrant and unfolded proteins induce cellular stresses and contributes in human to diseases and aging. Several cellular pathways combat the formation of these deleterious molecules. Recently, processes limiting the production of unwanted polypeptides through the co-translational degradation of their me...

G. Caulier, F. Mauxion, B. Séraphin · bioRxiv · 0 citations

Open access Sep 2026

TBPL2-dependent transcription controls RNA stability and cellular organization in growing oocytes

The data reveal that both nuclear and cytoplasmic organizations are profoundly disrupted in the absence of TBPL2-mediated transcription, indicating that TBPL2-mediated transcription is essential for maintaining proper cellular organization in growing oocytes, at least in part by ensuring the functional integrity of the...

Emmanuel Garcia Sanchez, Dylane Detilleux, Claire Richard et al. · bioRxiv · 0 citations