Evaluation of Sequential Phage-Antibiotic Therapy Reveals Enhanced Biofilm Control with Meropenem and Colistin in Clinical MDR Hypervirulent Klebsiella pneumoniae Strain.
Sequential phage-antibiotic treatment was effective against MDR-HvKp biofilms, with pre-phage exposure enhancing antibiotic access through biofilm disruption, and the bacteriostatic nature of tigecycline reduced efficacy by affecting phage replication.